One Coen Brother is either not enough, or one too many. If it’s the wrong Coen. Oh brother.

That’s “Drive-Away Dolls,” a crude, clunky and carnal romp that runs bits and pieces of “Raising Arizona,” “Fargo” and “Burn Before Reading” through a lesbian bar tour of the southeast, and can manage barely a laugh in the process.

Left to his own devices, Ethan Coen — sans brother Joel — is just a generic vulgarian grasping for laughs out of an ill-considered cartoon of a cultural commentary comedy.

Margaret Qualley of “Once Upon a Time…in Hollywood” and Geraldine Viswanathan of “The Beanie Bubble” and the best of the COVID lockdown rom-coms “7 Days” co-star as gay women of 1999 Philly who take on a one-way drive car delivert to Tallahassee just to get out of town.

Cocky womanizer Jamie (Qualley) just got caught cheating, and buttoned-down and uptight Marian (Viswanathan) was going to the corner of Florida aptly nicknamed “Florabama,” and not because of its enlightenment and tolerance.

“Why would anybody go to Tallahassee, Florida?”

“My Aunt lives there!”

“Can’t she MOVE?”

Good one. No. Seriously. Sentencing DeSantis there seems like fitting punishment.

But the guy who arranges such drive-and-deliveries, Curlie (deadpan Bill Camp) has these mobsters shipping a 1980s drug dealer (aluminum case) briefcase there he’s working for. He mistakenly assigns the Sapphic sisters to that beat-up Dodge Aries by mistake.

We know what our travelers don’t, that the guy who owned the case (Pedro Pascal) was murdered by corkscrew to acquire that case. And whatever is in it, somebody wants it real bad.

Jamie doesn’t know, and taking out an old-fashioned fold-out map and marking up the Southeast’s finest selection of lesbian (rhymes with “bike”) bars, she plots their trek. They’re in no rush. “Dismantling the patriarchy” takes time. And Marian...has needs.

The disappointed mob lieutenant (Colman Domingo) and his goons (Joey Slotnick and C.J. Wilson) will just have to find a way to track them in this pre-cellular phone (almost) era. Questioning Jamie’s ex (Beanie Feldstein) is just the beginning of their problems.

Marian’s planned ahead. She’s got a copy of Henry James’ “The Europeans” to polish off. The head mobster is reading James’ “The Golden Bowl.” To which the viewer can sigh and titter, “Better them than me.”

Qualley trots out Mama Andie Macdowell’s drawl, Viswanathan does her best tight-ass turn, Feldstein goes tough-broad to limited effect, and none of the big names in glorified cameos can stop the bleeding.

Bar pick-ups and a spirited encounter with the “very committed lesbians” of a woman’s college soccer team, what passes for a resort hotel in Tallahassee, intrigues involving a certain “family values” Senator (Matt Damon) and a hump-anything chihuahua give one an appreciation of how low this Coen will go, letting us figure that the Coen married to Frances McDormand is the classy one, the guy who got Denzel to make “Macbeth.”

Maybe. Maybe not. But suffice it to say, Ethan’s movie-making without Joel is lacking the sounding board that made even their worst excesses (“Hail, Caesar!”) marginally better than this.

Rating: R,  R, Full Nudity, Crude Sexual Content, violence and profanity

Cast: Margaret Qualley, Geraldine Viswanathan, Colman Domingo, Bill Camp, Beanie Feldstein, Pedro Pascal and Matt Damon

Credits: Directed by Ethan Coen, scripted by Ethan Coen and Tricia Cooke. A Focus Features release.

Running time: 1:24