Frustration can be a great launching point for laughs, and the comedy “Hangdog” revels in it.

Our “hero” is a frustrated “big city” hipster relocated to Portland, Maine. Uptight Walt is seriously out of step with the laid-back Mainers.

Walt, played by Desmin Borges of “Only Murders in the Building,” has given up on his advertising art director dreams and is both “proud” and secretly resentful of all the “new app” success about to rain down on his adoring and adorable girlfriend, Wendy (Kelly O’Sullivan of “Cha Cha Reel Smooth” and “Saint Frances”).

When she proposes to him because he’s hesitant to pull that trigger, he’s upset. And he’s a tad irked at the affection she’s showering on their adopted terrier mix, Tony.

Imagine how frustrated he is when she entrusts him with the dog while she travels to New York to pitch her “Etsy of sustainable shopping” app to backers.

He can “handle a dog,” he assures her. “How f—–g hard can it be?”

We if not he instantly consider those to be “famous last words.” “Hangdog” Walt loses Tony in a moment of self-involved carelessness. “Hangdog” is about the comically frustrating Portland odyssey Walt undertakes to recover Tony before Wendy returns to find her beloved “fur baby” gone.

Husband and wife director and writers Matt Cascella and Jen Cordery take us on a tour of scenic, street-musicians, coffee shops and weed dispensaries Portland, from its seaside parks and West End to Peaks Island, all places Walt papers with fliers about Tony — promising a reward — many locales featuring quirky locals for him to encounter.

There’s the droll lesbian neighbor (Barbara Rosenblat) who chuckles at his angst, suggests he discover the joys of “zero f—s” living and the sketchy fishing boat skipper who has “information” about the dog — or about how to get over grieving for a lost pet.

Walt lies to Wendy on the phone and desperately follows up each lead, leading him to Peaks Island, where he meets a pickle-packing fisherman (Steve Coulter) and locals who might be unsavory enough to have an idea about the fate of his girlfriend’s dog.

Bourges, always seen in a black stocking cap and a look that varies from stricken to “given up,” is a delight in the title role — driving the viewer a little nuts with his clumsiness, spinelessness and gullibility, letting us exult as he does when he rents a bike and forgets his anxiety, just for a few minutes, on that island in the harbor.

Rosenblat and Coulter amuse, and “Stranger Things” and “Orange is the New Black” alumna Catherine Curtin brings a comically scary edge to her menacing mama who figures in the story’s darker intrigues.

And for all the relationship insights dog-lovers-savvy our screenwriters fold into this slight, low-stakes tale, they wisely let underfilmed Portland itself take on a co-starring role in a movie that reminds us that Left Coast “Portlandia” has nothing on Stephen King country when it comes to quirky, colorful and comically-frustrating folks and folkways.

Rating: unrated, comical violence, drug use, profanity

Cast: Desmin Borges, Kelly O’Sullivan, Barbara Rosenblat, Catherine Curtin and Steve Coulter

Credits: Directed by Matt Cascella, scripted by Matt Cascella and Jen Cordery. A Good Deeds Entertainment release.

Running time: 1:30